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Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study.

Department of Internal Medicine, VieCuri Medical Centre, Venlo, The Netherlands. Department of Internal Medicine, Research School NUTRIM, Maastricht University Medical Centre+, Maastricht, The Netherlands. Department of Surgery, VieCuri Medical Centre, Venlo, The Netherlands. Department of Orthopedic Surgery, VieCuri Medical Centre, Venlo, The Netherlands. Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, The Netherlands. Department of Clinical Pharmacy and Toxicology, Maastricht University, Maastricht, The Netherlands. Department of Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, New South Wales, Australia. School of Medicine, The University of Notre Dame, Sydney, New South Wales, Australia. School of Population Health, UNSW, Sydney, New South Wales, Australia. School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia. Department of Internal Medicine, Subdivision Rheumatology, Research School CAPHRI, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands. Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Department of Internal Medicine, VieCuri Medical Centre, Venlo, The Netherlands jvdbergh@viecuri.nl.

BMJ open. 2022;(7):e058983
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Abstract

OBJECTIVES To evaluate the risk of subsequent fractures in patients who attended the Fracture Liaison Service (FLS), with and without incident falls after the index fracture. DESIGN A 3-year prospective observational cohort study. SETTING An outpatient FLS in the Netherlands. PARTICIPANTS Patients aged 50+ years with a recent clinical fracture. OUTCOME MEASURES Incident falls and subsequent fractures. RESULTS The study included 488 patients (71.9% women, mean age: 64.6±8.6 years). During the 3-year follow-up, 959 falls had been ascertained in 296 patients (60.7%) (ie, fallers), and 60 subsequent fractures were ascertained in 53 patients (10.9%). Of the fractures, 47 (78.3%) were fall related, of which 25 (53.2%) were sustained at the first fall incident at a median of 34 weeks. An incident fall was associated with an approximately 9-fold (HR: 8.6, 95% CI 3.1 to 23.8) increase in the risk of subsequent fractures. CONCLUSION These data suggest that subsequent fractures among patients on treatment prescribed in an FLS setting are common, and that an incident fall is a strong predictor of subsequent fracture risk. Immediate attention for fall risk could be beneficial in an FLS model of care. TRIAL REGISTRATION NUMBER NL45707.072.13.

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Publication Type : Observational Study

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